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Biophysical pathology in cancer transformation
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SYSNO ASEP 0440282 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Biophysical pathology in cancer transformation Author(s) Pokorný, Jiří (URE-Y) RID
Pokorný, Jan (FZU-D) RID, ORCIDSource Title Journal of Clinical & Experimental Oncology - ISSN 2324-9110
S1, Nov (2013), s. 1-9Number of pages 9 s. Publication form Online - E Language eng - English Country US - United States Keywords cancer biophysics ; Warburg effect ; reverse Warburg effect ; biological electrodynamics ; coherent states Subject RIV BO - Biophysics R&D Projects GAP102/11/0649 GA ČR - Czech Science Foundation (CSF) Institutional support FZU-D - RVO:68378271 ; URE-Y - RVO:67985882 DOI 10.4172/2324-9110.S1-003 Annotation Energy supply to biological systems excites and sustains the state far from thermodynamic equilibrium, a necessary condition for life. Energy processing by mitochondria forms a strong static electric field which causes ordering of water, establishing conditions for generation of the electromagnetic field by microtubules. Disturbances of the energy supply system result in pathological states (disturbances of oxidative metabolism in cancer). Due to nonlinear properties of microtubule oscillations the frequency spectra of the electromagnetic field generated by cancer cells may be rebuilt and shifted in comparison to standard frequency spectra of the tissue. Tissue interactions are changed. A cancer cell disassociates itself from interactions with healthy cells, evades the regulation and control of tissue, and may move outside its assigned position. Mitochondrial dysfunction in cancers is distinct from the normal function in healthy cells and should be targeted for selective treatment. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2015
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