Exploiting end group functionalization for the design of antifouling bioactive brushes

0428662 - ÚMCH 2015 RIV GB eng J - Journal Article
Kuzmyn, Andrii - de los Santos Pereira, Andres - Pop-Georgievski, Ognen - Bruns, M. - Brynda, Eduard - Rodriguez-Emmenegger, Cesar
Exploiting end group functionalization for the design of antifouling bioactive brushes.
Polymer Chemistry. Roč. 5, č. 13 (2014), s. 4124-4131. ISSN 1759-9954. E-ISSN 1759-9962
R&D Projects: GA ČR GAP205/12/1702; GA ČR(CZ) GAP108/11/1857; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61389013
Keywords : click chemistry * end-group functionalization * non-fouling
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.520, year: 2014

Biologically active surfaces are essential in many applications in the fields of biosensing, bioimplants, and tissue engineering. However, the introduction of bioactive motifs without impairment of their ability to resist non-specific interactions with biological media remains a challenge. Herein, we present a straightforward, facile strategy for the creation of bioactive surfaces based on the end-group biofunctionalization of state-of-the-art polymer brushes via an ultra-fast Diels–Alder “click” reaction. Surface-initiated atom transfer radical polymerization is employed to grow antifouling polymers preserving the end groups. These groups are then further converted to a reactive cyclopentadienyl moiety and exploited for the immobilization of biomolecules on the topmost layer of the brush. The minimal chemical modification of the antifouling polymer brush accounts for the full preservation of the fouling resistance of the surface even after biofunctionalization, which is critical for the aforementioned applications.
Permanent Link: http://hdl.handle.net/11104/0234406