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Biological effects of CZF (cobalt zinc ferrite) nanoparticles in rat bone marrow mesenchymal stem cells
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SYSNO ASEP 0425607 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Biological effects of CZF (cobalt zinc ferrite) nanoparticles in rat bone marrow mesenchymal stem cells Author(s) Novotná, Božena (UEM-P)
Turnovcová, Karolína (UEM-P) ORCID
Veverka, Miroslav (FZU-D) RID
Rössner ml., Pavel (UEM-P) RID, ORCID
Bagryantseva, Yana (UEM-P)
Herynek, V. (CZ)
Syková, Eva (UEM-P) RID
Jendelová, Pavla (UEM-P) RID, ORCIDSource Title 2nd QNano Integrating Conference. -, 2013
S. 160-160Number of pages 1 s. Action QNano Integrating Conference /2./ Event date 27.02.2013-01.03.2013 VEvent location Praha Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords safety ; cobalt zinc ferrite ; contrast agent ; cell labeling Subject RIV FP - Other Medical Disciplines R&D Projects GAP304/12/1370 GA ČR - Czech Science Foundation (CSF) Institutional support FZU-D - RVO:68378271 ; UEM-P - RVO:68378041 Annotation To monitor the fate of transplanted cells within the organism, several non-invasive techniques have been introduced, including magnetic resonance imaging (MRI) of cells labeled with a contrast agent prior to grafting. Our previous study demonstrated a severe oxidative injury to lipids, proteins and DNA of human bone marrow mesenchymal stem cells as a result of their labeling with superparamagnetic iron oxide nanoparticles (SPIONs). CZF nanoparticles represent another type of contrast agent based not only on iron, but also on cobalt and zinc (Co0.5Zn0.5Fe2O4+γ), with a ferrite core encapsulated by amorphous silica. The present study was performed with the aim of determining the safe concentration of CZF nanoparticles with respect to oxidative damage to biological macromolecules. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2014
Number of the records: 1