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Chelating polymeric particles intended for the therapy of Wilson’s disease
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SYSNO ASEP 0395188 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chelating polymeric particles intended for the therapy of Wilson’s disease Author(s) Škodová, Michaela (UMCH-V) RID
Kučka, Jan (UMCH-V) RID, ORCID
Vetrík, Miroslav (UMCH-V) RID, ORCID
Skopal, Jan (UMCH-V)
Walterová, Zuzana (UMCH-V)
Sedláček, Ondřej (UMCH-V) RID, ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Mattová, J. (CZ)
Poučková, P. (CZ)
Urbánek, P. (CZ)
Hrubý, Martin (UMCH-V) RID, ORCIDSource Title Reactive and Functional Polymers. - : Elsevier - ISSN 1381-5148
Roč. 73, č. 11 (2013), s. 1426-1431Number of pages 6 s. Language eng - English Country NL - Netherlands Keywords Wilson’s disease ; polymer beads ; copper metabolism Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects GAP304/12/0950 GA ČR - Czech Science Foundation (CSF) GA13-08336S GA ČR - Czech Science Foundation (CSF) Institutional support UMCH-V - RVO:61389013 UT WOS 000326431800004 DOI 10.1016/j.reactfunctpolym.2013.07.010 Annotation Wilson’s disease is a genetic disorder that leads to a high accumulation of copper in multiple organs with subsequent toxic effects. In this paper, a gentle therapy to eliminate harmful copper concentrations in patients with Wilson’s disease is proposed using an oral administration of insoluble polymeric sorbents containing selective chelating groups for copper(II). The sorbents contained triethylenetetramine, N,N-di(2-pyridylmethyl)amine, 8-hydroxyquinoline or 8-hydroxyquinoline-5-sulfonic acid chelating groups bound to a methacrylate-based macroporous support. Nearly quantitative copper(II) uptake within minutes was achieved in buffers modeling the pH range present in the gastric environment (pH 2.0 and 4.0). The sorbents demonstrated chelating selectivity for copper(II) against zinc(II) with ratios of up to 1321. The sorbents demonstrated sufficient stability of the copper complexes against rechelation using studies in a model environment for the small intestine (the presence of chelating amino acids, pH 6.8). Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2014
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