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Age-related changes in the acoustic startle reflex in Fischer 344 and Long Evans rats
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SYSNO ASEP 0383080 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Age-related changes in the acoustic startle reflex in Fischer 344 and Long Evans rats Author(s) Rybalko, Natalia (UEM-P) RID
Bureš, Zbyněk (UEM-P) RID, ORCID
Burianová, Jana (UEM-P)
Popelář, Jiří (UEM-P) RID
Poon, P. W. F. (TW)
Syka, Josef (UEM-P) RIDSource Title Experimental Gerontology. - : Elsevier - ISSN 0531-5565
Roč. 47, č. 12 (2012), s. 966-973Number of pages 8 s. Language eng - English Country US - United States Keywords aging ; acoustic startle response ; prepulse inhibition Subject RIV FH - Neurology R&D Projects GAP304/12/1342 GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) GCP303/11/J005 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000312120100011 DOI 10.1016/j.exger.2012.09.001 Annotation Hearing thresholds, the strength of the acoustic startle responses and the efficiency of the prepulse inhibition were assessed in young, middle-aged, and aged Long Evans and Fischer 344 rats. Fischer 344 rats showed larger age-related hearing threshold shifts and lower amplitudes of startle responses at an earlier age than in Long Evans rats. A reduction of the prepulse inhibition was observed in aged rats of both strains. The results indicate that the acoustic startle response may serve as an indicator of central presbycusis. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2013
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