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CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis
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SYSNO ASEP 0377338 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis Author(s) Neckář, Jan (FGU-C) RID, ORCID
Šilhavý, Jan (FGU-C) RID, ORCID
Zídek, Václav (FGU-C) RID
Landa, Vladimír (FGU-C) RID
Mlejnek, Petr (FGU-C) RID, ORCID
Šimáková, Miroslava (FGU-C) RID, ORCID
Seidman, J. G. (US)
Seidman, Ch. (US)
Kazdová, L. (CZ)
Klevstig, M. (CZ)
Novák, F. (CZ)
Vecka, M. (CZ)
Papoušek, František (FGU-C)
Houštěk, Josef (FGU-C) RID, ORCID
Drahota, Zdeněk (FGU-C) RID, ORCID
Kurtz, T. W. (US)
Kolář, František (FGU-C) RID, ORCID, SAI
Pravenec, Michal (FGU-C) RID, ORCIDSource Title Physiological Genomics. - : American Physiological Society - ISSN 1094-8341
Roč. 44, č. 2 (2012), s. 173-182Number of pages 10 s. Language eng - English Country US - United States Keywords Cd36 ; spontaneously hypertensive rat ; arrhythmias ; infarct size ; gene expression profiles Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects ME08006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NR9359 GA MZd - Ministry of Health (MZ) NR9387 GA MZd - Ministry of Health (MZ) NS9757 GA MZd - Ministry of Health (MZ) NS10504 GA MZd - Ministry of Health (MZ) IAA500110805 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAAX01110901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200520703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GD305/08/H037 GA ČR - Czech Science Foundation (CSF) GAP301/10/0756 GA ČR - Czech Science Foundation (CSF) 7E10067 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000300048700007 DOI 10.1152/physiolgenomics.00083.2011 Annotation We analyzed the effects of mutant Cd36 on susceptibility to ischemic ventricular arrhythmias and myocardial infarction in adult SHR-Cd36 transgenic rats with wild type Cd36 compared to age-matched SHR controls. Our results showed that transgenic expression of Cd36 plays an important role in modulating the incidence and severity of ischemic and reperfusion ventricular arrhythmias and myocardial infarct size induced by coronary artery occlusion. The proarrhythmic effect of Cd36 transgene appears to be dependent on adrenergic stimulation Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2013
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