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Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics
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SYSNO ASEP 0310942 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics Title Balancujici selekce na dvou MHC Class II genech je zprostředkována více druhy parazitů: výsledky vícerozměrných analýz a populační genetiky Author(s) Tollenaere, C. (FR)
Bryja, Josef (UBO-W) RID, SAI, ORCID
Galan, M. (FR)
Cadet, P. (FR)
Deter, J. (FR)
Chaval, Y. (FR)
Berthier, K. (FR)
Ribas Salvador, A. (ES)
Voutilainen, L. (FI)
Laakkonen, J. (FI)
Henttonen, H. (FI)
Cosson, J.-F. (FR)
Charbonnel, N. (FR)Source Title Journal of Evolutionary Biology - ISSN 1010-061X
Roč. 21, č. 5 (2008), s. 1307-1320Number of pages 14 s. Language eng - English Country GB - United Kingdom Keywords co-inertia ; DQA and DRB MHC genes ; immunogenetics ; multivariate analysis ; parasite-mediated balancing selection Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000258379600014 EID SCOPUS 49549105509 DOI 10.1111/j.1420-9101.2008.01563.x Annotation We investigated the factors mediating selection acting on two MHC class II genes (DQA and DRB) in water vole (Arvicola scherman) natural populations in the French Jura Mountains. Population genetics showed significant homogenity in allelic frequencies at the DQA1 locus as opposed to neutral markers (nine microsatellites), indicating balancing selection acting on this gene. Moreover, almost exhaustive screening for parasites, including gastrointestinal helminths, brain coccidia and antibodies against viruses responsible for zoonoses, was carried out. We applied a co-inertia approach to the genetic and parasitological data sets to avoid statistical problems related to multiple testing. Two alleles, Arte-DRB-11 and Arte-DRB-15, displayed antagonistic associations with the nematode Trichuris arvicolae, revealing the potential parasite-mediated selection acting on DRB locus. Selection mechanisms acting on the two MHC class II genes thus appeared different. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2009
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