New approaches to synthesis of C-deoxyribosides starting from C-alkynyldeoxyribosides

0309900 - ÚOCHB 2009 RIV CZ eng C - Conference Paper (international conference)
Novák, P. - Hocek, Michal - Kotora, Martin
New approaches to synthesis of C-deoxyribosides starting from C-alkynyldeoxyribosides.
[Nový přístup k syntéze C-deoxyribosidů vycházející z C-alkynyldeoxyribosidů.]
Chemistry of Nucleic Acid Components. Praha: Institute of Organic Chemistry and Biochemistry ASCR, 2008 - (Hocek, M.), s. 168-172. Collection Symposium Series, 10. ISBN 978-80-86241-29-6.
[Symposium on Chemistry of Nucleic Acid Components /14./. Český Krumlov (CZ), 08.06.2008-13.06.2008]
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : C-deoxyribosides * cyclotrimerization * metal complexes
Subject RIV: CC - Organic Chemistry

Various C-aryldeoxyribosides were conveniently prepared from the C-alkynyldeoxyribosides in good yields. The underlying strategy is based on [2+2+2]-cyclotrimerization catalyzed by rhodium and ruthenium complexes. The reaction could be carried out under ambient conditions or microwave irradiation depending on the degree of substitution.

Různé C-aryldeoxyribosidy byly připraveny z C-alkynyldeoxyribosidů v dobrých výtěžcích. Popsaná strategie je postavena na [2+2+2]-cyklotrimerizacích katalyzovaných komplexy rhodia a ruthenia probíhajících za pokojové teploty nebo v mikrovlném reaktoru.
Permanent Link: http://hdl.handle.net/11104/0161917