Proteome study of Francisella tularensis live vaccine strain-containing phagosome in Bcg/Nramp1 congenic macrophages: Resistant allele contributes to permissive environment and susceptibility to infection

0213517 - UZFG-Y 20023133 RIV DE eng J - Journal Article
Kovářová, Hana - Halada, Petr - Man, P. - Golovliov, I. - Špaček, J. - Porkertová, S. - Nečasová, R.
Proteome study of Francisella tularensis live vaccine strain-containing phagosome in Bcg/Nramp1 congenic macrophages: Resistant allele contributes to permissive environment and susceptibility to infection.
Proteomics. č. 2 (2002), s. 85-93. ISSN 1615-9853. E-ISSN 1615-9861
R&D Projects: GA ČR GA310/99/1185; GA MŠMT LN00A033; GA AV ČR KSK5052113
Keywords : innate immunity * phagosome * francisella tularensis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.007, year: 2002

The phagocytosis of pathogens by macrophages classically initiates maturation of the phagosome that involves a dynamic exchange of phagosomal components with intracellular compartments of the endocytic pathway. The intracellular microorganisms have developed sophisticated mechanism to sense enviromental conditions and respond to them by phenotypic alterations that ensure their adaptation, survival and proliferation inside the cell.
Permanent Link: http://hdl.handle.net/11104/0109053