A study of biomarkers in cervical carcinoma and clinical correlation of the novel biomarker MN

0191254 - UMG-J 20010324 RIV US eng J - Journal Article
Brewer, C. A. - Liao, S. Y. - Wilczynski, S. P. - Pastoreková, S. - Pastorek, J. - Závada, Jan - Kurosak, T. - Manetta, A. - Berman, M. L. - DiSaia, P. J. - Stanbridge, E. J.
A study of biomarkers in cervical carcinoma and clinical correlation of the novel biomarker MN.
Gynecologic Oncology. Roč. 63, č. 3 (1996), s. 337-344. ISSN 0090-8258. E-ISSN 1095-6859
R&D Projects: GA ČR GA301/96/0843
Keywords : carbonic anhydrase 9 * cervical carcinoma * prognostic
Subject RIV: EB - Genetics ; Molecular Biology

MN protein was overexpressed in all cervical carcinomas and quantitatively varied with the histological subtype. Lower expression of MN correlated with adenosquamous and less differentiated histology, as well as with HPV negativity. In stage IB and IIA cancers, low expression of MN was associated with deeper cervical stromal invasion. Low expression also correlated with lymph node metastases. MN is emerging as potentially important new biomarker for cervical carcinoma.Low expression of MN appears to correlate with several adverse prognostic features.
Permanent Link: http://hdl.handle.net/11104/0087009