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Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis
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SYSNO ASEP 0188725 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis Author(s) Wang, D. (US)
Pechar, Michal (UMCH-V) RID, ORCID
Kopečková, P. (US)
Brömme, D. (US)
Kopeček, J. (US)Source Title Intelligent Drug Delivery Systems Better and Safer Therapy. - Istanbul : Hacettepe University Pharmacy Faculty, 2002 - ISBN 975-491-126-6 Pages s. 12-13 Number of pages 2 s. Action International Pharmaceutical Technology Symposium /11./ Intelligent Drug Delivery Systems Better and Safer Therapy Event date 09.09.2002-11.09.2002 VEvent location Istanbul Country TR - Turkey Event type WRD Language eng - English Country TR - Turkey Keywords Cathepsin K Subject RIV CE - Biochemistry R&D Projects KSK4055109 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Annotation We synthesized novel bioconjugates of cathepsin K inhibitor, 1-(N-benzyl-oxy-carbonylleucyl)-5-(phenylalanylleucyl)-carbo-hydrazide with a-methoxy poly(ethylene glycol), semitelechelic poly[N-(2-hydroxypropyl)-methacrylamide] and HPMA copolymers containing reactive side-chans. The inhibitory activity of macromolecular inhibitors for cysteine proteinases as well as their ability to inhibit cathepsin K activity in synovial fibroblasts were evaluated. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2003
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