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Surface membrane glycosylation of EL-4 cells: the impact of free or N-(2-hydroxypropyl)methacrylamide (HPMA) bound doxorubicin
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SYSNO ASEP 0099643 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Surface membrane glycosylation of EL-4 cells: the impact of free or N-(2-hydroxypropyl)methacrylamide (HPMA) bound doxorubicin Title Glykosylace povrchové membrány EL-4 buněk: vliv volného nebo N-(2-hydroxypropyl)methacrylamide (HPMA) vázaného doxorubicinu Author(s) Kovář, Lubomír (MBU-M)
Etrych, Tomáš (UMCH-V) RID, ORCID
Šubr, Vladimír (UMCH-V) RID, ORCID
Strohalm, Jiří (UMCH-V)
Sklenář, Jan (MBU-M)
Chytil, Petr (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
Říhová, Blanka (MBU-M) RIDSource Title International Workshop on Drug Delivery Systems /5./. - Praha : Springer, 2007 Pages s. 27-27 Number of pages 1 s. Action International Workshop on Drug Delivery Systems /5./ Event date 15.05.2007-18.5.2007 VEvent location Třeštˇ Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords doxorubicin Subject RIV EC - Immunology R&D Projects GA305/05/2268 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) AV0Z40500505 - UMCH-V (2005-2011) Annotation In those experimenst we studied the possible impace of CD43 as highly glycosylated molecule in cells exposed to free doxorubicin (Dox) or to conjugates consisting of HPMA copolymer backbone to which the drug is conjugated via enzymatically (PK1 conjugate) or pH sensitive, hydrolytically cleavable bond (hydrazone conjugate, HYD). Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2008
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