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Surface membrane glycosylation of EL-4 cells: the impact of free or N-(2-hydroxypropyl)methacrylamide (HPMA) bound doxorubicin
- 1.0099643 - MBÚ 2008 RIV CZ eng C - Conference Paper (international conference)
Kovář, Lubomír - Etrych, Tomáš - Šubr, Vladimír - Strohalm, Jiří - Sklenář, Jan - Chytil, Petr - Ulbrich, Karel - Říhová, Blanka
Surface membrane glycosylation of EL-4 cells: the impact of free or N-(2-hydroxypropyl)methacrylamide (HPMA) bound doxorubicin.
[Glykosylace povrchové membrány EL-4 buněk: vliv volného nebo N-(2-hydroxypropyl)methacrylamide (HPMA) vázaného doxorubicinu.]
International Workshop on Drug Delivery Systems /5./. Praha: Springer, 2007, s. 27-27.
[International Workshop on Drug Delivery Systems /5./. Třeštˇ (CZ), 15.05.2007-18.5.2007]
R&D Projects: GA ČR GA305/05/2268
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z40500505
Keywords : doxorubicin
Subject RIV: EC - Immunology
In those experimenst we studied the possible impace of CD43 as highly glycosylated molecule in cells exposed to free doxorubicin (Dox) or to conjugates consisting of HPMA copolymer backbone to which the drug is conjugated via enzymatically (PK1 conjugate) or pH sensitive, hydrolytically cleavable bond (hydrazone conjugate, HYD).
V těchto pokusech jsme sledovali vliv vysoce glykosylované povrchové molekuly CD43 u buněk vystaveným volnému doxorubicinu nebo doxorubicinu konjugovanému k HPMA polymeru
Permanent Link: http://hdl.handle.net/11104/0158196
Number of the records: 1