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A paradoxical hypothesis: Might a controlled immune supression help to rescue the immune response in a pro-inflammatory tumor microenvironment?

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    SYSNO ASEP0099282
    Document TypeC - Proceedings Paper (int. conf.)
    R&D Document TypeConference Paper
    TitleA paradoxical hypothesis: Might a controlled immune supression help to rescue the immune response in a pro-inflammatory tumor microenvironment?
    TitleParadoxní hypoteza: Může kontrolovaná imunosuprese pomoci vyvolat imunitní odpověď v nádorovém prostředí?
    Author(s) Vannucci, Luca (MBU-M) RID, ORCID
    Source Titlenternational Conference of the International Society of Cancer Microenvironment /4./. - Florencie : AACR, 2007
    Pagess. 47-47
    Number of pages1 s.
    Actionnternational Conference of the International Society of Cancer Microenvironment /4./
    Event date06.03.2007-10.03.2007
    VEvent locationFlorencie
    CountryIT - Italy
    Event typeWRD
    Languageeng - English
    CountryIT - Italy
    Keywordsimmunity ; cancer
    Subject RIVEC - Immunology
    R&D ProjectsIAA500200510 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    CEZAV0Z50200510 - MBU-M (2005-2011)
    AnnotationWe propose the hypothesis that we need temporarely block the immunity to restart an effective anticancer response. The hypothesis is based on the new knowledge about proinflammatory cancer microenvironment and tumor immune escape. Carcer-bearing animals that received mild immunosuppressive treatment for a short time had reduction of cancer growth and lymphocytes were able to vigourosly produce IFN-gamma
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2008
Number of the records: 1  

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