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A paradoxical hypothesis: Might a controlled immune supression help to rescue the immune response in a pro-inflammatory tumor microenvironment?
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SYSNO ASEP 0099282 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title A paradoxical hypothesis: Might a controlled immune supression help to rescue the immune response in a pro-inflammatory tumor microenvironment? Title Paradoxní hypoteza: Může kontrolovaná imunosuprese pomoci vyvolat imunitní odpověď v nádorovém prostředí? Author(s) Vannucci, Luca (MBU-M) RID, ORCID Source Title nternational Conference of the International Society of Cancer Microenvironment /4./. - Florencie : AACR, 2007 Pages s. 47-47 Number of pages 1 s. Action nternational Conference of the International Society of Cancer Microenvironment /4./ Event date 06.03.2007-10.03.2007 VEvent location Florencie Country IT - Italy Event type WRD Language eng - English Country IT - Italy Keywords immunity ; cancer Subject RIV EC - Immunology R&D Projects IAA500200510 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50200510 - MBU-M (2005-2011) Annotation We propose the hypothesis that we need temporarely block the immunity to restart an effective anticancer response. The hypothesis is based on the new knowledge about proinflammatory cancer microenvironment and tumor immune escape. Carcer-bearing animals that received mild immunosuppressive treatment for a short time had reduction of cancer growth and lymphocytes were able to vigourosly produce IFN-gamma Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2008
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