Novel glutathione-sensitive linkage for polymer – drug conjugates

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SYSNO ASEP	0042633
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Novel glutathione-sensitive linkage for polymer – drug conjugates
Title	Sulfenamid – nový typ reduktivně štěpitelné vazby pro dopravu a řízené uvolňování léčiv
Author(s)	Studenovský, Martin (UMCH-V)_{RID, ORCID} Ulbrich, Karel (UMCH-V)_RID
Source Title	CRS Transactions. - Vienna : Controlled Release Society, 2006
Pages	p682/1-p682/2
Number of pages	2 s.
Publication form	CD-ROM - CD-ROM
Action	Annual Meeting & Exposition of the Controlled Release Society /33./
Event date	22.07.2006-26.07.2006
VEvent location	Vienna
Country	AT - Austria
Event type	WRD
Language	eng - English
Country	AT - Austria
Keywords	anticancer agents ; conjugates
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	GA204/05/2255 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
Annotation	The sulfenamide bond was proposed as a readily cleavable linkage for polymer - drug conjugates. Two different low molecular model compounds containing the sulfenamide bond were synthesized and examined with regard to the ability to thiolysis by intracellular glutathione and hydrolytic stability as well.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2007

Number of the records: 1