Soluble MHC-peptide complexes induce rapid death of CD8+ CTL
1.
SYSNO ASEP
0025647
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Soluble MHC-peptide complexes induce rapid death of CD8+ CTL
Title
Solubilní komplexy MHC-peptidu indukují rychlou buněčnou smrt CD8+ CTL
Author(s)
Cebecauer, M. (CH) Guillaume, P. (CH) Hozák, Pavel (UEM-P) Mark, S. (CH) Everett, H. (CH) Schneider, P. (CH) Luescher, I.F. (CH)
Source Title
Journal of Immunology. - : American Association of Immunologists
- ISSN 0022-1767
Roč. 174, č. 11 (2005), s. 6809-6819
Number of pages
11 s.
Language
eng - English
Country
US - United States
Keywords
MHC-peptide
Subject RIV
EA - Cell Biology
R&D Projects
IAA5039202 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
GA204/04/0108 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z50390512 - UEM-P (2005-2011)
Annotation
Soluble MHC-peptide (pMHC) complexes, commonly referred to as tetramers, are widely used to enumerate and to isolate Ag-specific CD8(+) CTL. Our results show that soluble pMHC complexes containing long linkers are recommended to prevent T cell death, whereas those containing short linkers can be used to eliminate Ag-specific CTL.
