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Eco-evolutionary dynamics of host-microbiome interactions in a natural population of closely related mouse subspecies and their hybrids
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SYSNO ASEP 0603231 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Eco-evolutionary dynamics of host-microbiome interactions in a natural population of closely related mouse subspecies and their hybrids Author(s) Ferreira, S. C. M. (AT)
Jarquín-Díaz, V. H. (DE)
Planillo, A. (DE)
Ďureje, Ľudovít (UBO-W) ORCID, RID, SAI, SAI
Martincová, Iva (UBO-W) ORCID
Kramer-Schadt, S. (DE)
Forslund-Startceva, S. K. (DE)
Heitlinger, E. (DE)Number of authors 8 Article number 20241970 Source Title Proceedings of the Royal Society B-Biological Sciences. - : Royal Society Publishing - ISSN 0962-8452
Roč. 291, č. 2037 (2024)Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords host-microbiome interactions ; species barriers ; hybridization ; microbiome ; spatial environment Subject RIV EG - Zoology OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Method of publishing Open access Institutional support UBO-W - RVO:68081766 UT WOS 001378846000009 EID SCOPUS 85212759712 DOI https://doi.org/10.1098/rspb.2024.1970 Annotation Closely related host species share similar symbionts, but the effects of host genetic admixture and environmental conditions on these communities remain largely unknown. We investigated the influence of host genetic admixture and environmental factors on the intestinal prokaryotic and eukaryotic communities (fungi, parasites) of two house mouse subspecies (Mus musculus domesticus and M. m. musculus) and their hybrids in two settings: (i) wild-caught mice from the European hybrid zone and (ii) wild-derived inbred mice in a controlled laboratory environment before and during a community perturbation (infection). In wild-caught mice, environmental factors strongly predicted the overall microbiome composition. Subspecies' genetic distance significantly influenced the overall microbiome composition, and each component (bacteria, parasites and fungi). While hybridization had a weak effect, it significantly impacted fungal composition. We observed similar patterns in wild-derived mice, where genetic distances and hybridization influenced microbiome composition, with fungi being more stable to infection-induced perturbations than other microbiome components. Subspecies' genetic distance has a stronger and consistent effect across microbiome components than differences in expected heterozygosity among hybrids, suggesting that host divergence and host filtering play a key role in microbiome divergence, influenced by environmental factors. Our findings offer new insights into the eco-evolutionary processes shaping host-microbiome interactions. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2025 Electronic address https://royalsocietypublishing.org/doi/10.1098/rspb.2024.1970
Number of the records: 1