Low-dimensional compounds containing bioactive ligands. \nPart XX: crystal structures, cytotoxic, antimicrobial activities and DNA/BSA binding of oligonuclear zinc complexes with halogen derivatives of 8-hydroxyquinoline

0570239 - FZÚ 2024 RIV CH eng J - Journal Article
Harmošová, M. - Kello, M. - Goga, M. - Tkáčiková, Ľ. - Vilková, M. - Sabolová, D. - Sovová, S. - Samoľová, Erika - Litecká, Miroslava - Kuchárová, V. - Kuchár, J. - Potočňák, I.
Low-dimensional compounds containing bioactive ligands.
Part XX: crystal structures, cytotoxic, antimicrobial activities and DNA/BSA binding of oligonuclear zinc complexes with halogen derivatives of 8-hydroxyquinoline.
Inorganic. Roč. 11, č. 2 (2023), č. článku 60. E-ISSN 2304-6740
R&D Projects: GA MŠMT LM2018110; GA MŠMT(CZ) LM2018124
Institutional support: RVO:68378271 ; RVO:61388980
Keywords : crystal structure * Zn complexes * 8-hydroxyquinoline * cytotoxicity * antimicrobial activity * DNA/BSA binding
OECD category: Condensed matter physics (including formerly solid state physics, supercond.); Inorganic and nuclear chemistry (UACH-T)
Impact factor: 2.9, year: 2022
Method of publishing: Open access

Two tetranuclear [Zn4Cl2(ClQ)6]2DMF and [Zn4Cl2(ClQ)6(H2O)2]4DMF, as well as three dinuclear [Zn2(ClQ)3(HClQ)3]I3, [Zn2(dClQ)2(H2O)6(SO4)] and [Zn2(dBrQ)2(H2O)6(SO4)], complexes (HClQ = 5-chloro-8-hydroxyquinoline, HdClQ = 5,7-dichloro-8-hydroxyquinoline and HdBrQ = 5,7-dibromo-8-hydroxyquinoline) were prepared as possible anticancer or antimicrobial agents and characterized by IR spectroscopy, elemental analysis and single crystal X-ray structure analysis. The stability of the complexes in solution was verified by NMR spectroscopy. Antiproliferative activity and selectivity of the prepared com plexes were studied using in vitro MTT assay against the HeLa, A549, MCF-7, MDA-MB-231, HCT116 and Caco-2 cancer cell lines and on the Cos-7 non-cancerous cell line.
Permanent Link: https://hdl.handle.net/11104/0342052