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Intraperitoneally administered native and lauroyl-modified hyaluronan films: Pharmacokinetic and metabolism studies
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SYSNO ASEP 0570210 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Intraperitoneally administered native and lauroyl-modified hyaluronan films: Pharmacokinetic and metabolism studies Author(s) Brtkova, B. (CZ)
Hermannová, M. (CZ)
Chmelař, J. (CZ)
Nešporová, K. (CZ)
Kocurková, Anna (BFU-R) ORCID
Kubala, Lukáš (BFU-R) RID, ORCID
Ambrožová, Gabriela (BFU-R) RID
Velebný, V. (CZ)
Šimek, M. (CZ)Number of authors 9 Article number 120201 Source Title Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 299, JAN 1 2023 (2023)Number of pages 9 s. Publication form Online - E Language eng - English Country NL - Netherlands Keywords Hyaluronan derivatives ; Implants ; Degradation ; Stable isotope ; Invivo evaluation Subject RIV CC - Organic Chemistry OECD category Physical chemistry Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000930582900004 EID SCOPUS 85139594399 DOI 10.1016/j.carbpol.2022.120201 Annotation Hyaluronan is being investigated extensively as a biocompatible and biodegradable material for use in biomedical applications. While the derivatization of hyaluronan broadens its potential therapeutic use, the pharmacokinetics and metabolization of the derivatives must be thoroughly investigated. The fate of intraperitoneally-applied native and lauroyl-modified hyaluronan films with varying degrees of substitution was investigated in-vivo employing an exclusive stable isotope-labelling approach and LC-MS analysis. The materials were gradually degraded in peritoneal fluid, lymphatically absorbed, preferentially metabolized in the liver and eliminated without any observable accumulation in the body. Hyaluronan acylation prolongs its presence in the peritoneal cavity depending on the degree of substitution. The safety of acylated hyaluronan derivatives was confirmed via a metabolic study that revealed its degradation into non-toxic metabolites, i.e. native hyaluronan and free fatty acid. Stable isotope-labelling with LC-MS tracking comprises a high-quality procedure for the investigation of the metabolism and biodegradability of hyaluronan-based medical products in-vivo. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2024 Electronic address https://www.sciencedirect.com/science/article/pii/S0144861722011067?via%3Dihub
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