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MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization
- 1.0569542 - BTÚ 2023 RIV US eng J - Journal Article
Vondráková, Jana - Frolíková, Michaela - Děd, Lukáš - Černý, Jiří - Postlerová, Pavla - Páleníková, Veronika - Šimoník, Ondřej - Nahácka, Zuzana - Bašus, Kryštof - Valášková, Eliška - Machan, R. - Pacey, A. - Holubcová, Z. - Koubek, P. - Ezrová, Zuzana - Park, S. - Liu, R. - Partha, R. - Clark, N. - Neužil, Jiří - Ikawa, M. - Erickson, K. - Lam, Kit S. - Moore, H. - Komrsková, Kateřina
MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization.
Science Advances. Roč. 8, č. 36 (2022), č. článku eabn0047. ISSN 2375-2548. E-ISSN 2375-2548
R&D Projects: GA ČR(CZ) GA18-11275S; GA ČR(CZ) GA22-30494S; GA ČR(CZ) GX21-04607X
Institutional support: RVO:86652036
Keywords : SPERM * REVEALS * PROTEIN * EGG * LIBRARY
OECD category: Reproductive biology (medical aspects to be 3)
Impact factor: 13.6, year: 2022
Method of publishing: Open access
https://www.science.org/doi/10.1126/sciadv.abn0047
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
Permanent Link: https://hdl.handle.net/11104/0340897
Number of the records: 1