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Genetic Susceptibility in Understanding of Pancreatic Ductal Adenocarcinoma Risk: A Decade-Long Effort of the PANDORA Consortium
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SYSNO ASEP 0568784 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genetic Susceptibility in Understanding of Pancreatic Ductal Adenocarcinoma Risk: A Decade-Long Effort of the PANDORA Consortium Author(s) Vodičková, Ludmila (UEM-P) RID
Horák, Josef (UEM-P) ORCID
Vodička, Pavel (UEM-P) RIDSource Title Cancer Epidemiology Biomarkers & Prevention. - : American Association for Cancer Research - ISSN 1055-9965
Roč. 31, č. 5 (2022), s. 942-948Number of pages 7 s. Language eng - English Country US - United States Keywords genome-wide association ; telomere length ; cancer risk ; loci ; variants OECD category Genetics and heredity (medical genetics to be 3) R&D Projects NU21-07-00247 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000795940100001 EID SCOPUS 85130112152 DOI 10.1158/1055-9965.EPI-21-1340 Annotation Pancreatic cancer, a complex disease, emerges as a severe health problem worldwide and it exhibits a poor prognosis and high mortality. Risk factors associated with sporadic pancreatic cancer remain poorly understood, even less is known about disease prognosis due to its rapid progression. The PANcreatic Disease ReseArch (PANDoRA) consortium, of which the authors are members, was established to coordinate the efforts of different research groups to uncover new genetic factors for pancreatic cancer risk, response to treatment, and patient survival. PANDoRA consortium has contributed to the identification of several low-penetrance risk loci for the disease both by candidate variants approach and genome-wide association studies, including those in cell-cycle and DNA damage response, telomere homeostasis, SCL and ABC transporters, ABO locus variability, mitochondrial metabolism and it participated on collaborative genome-wide association study approach and implementation of a search for functional-based pancreatic cancer risk loci and long noncoding RNAs. Complex studies covering genetic, environmental and microenvironmental factors in the pancreatic cancer onset, progression and its prognosis are warranted. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://aacrjournals.org/cebp/article/31/5/942/694745/Genetic-Susceptibility-in-Understanding-of
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