Quality assessment of niosomal suspensions

0567743 - FZÚ 2024 RIV US eng J - Journal Article
Ježková, M. - Šrom, O. - George, A.H. - Kereiche, S. - Rohlíček, Jan - Šoós, M.
Quality assessment of niosomal suspensions.
Journal of Colloid and Interface Science. Roč. 631, Feb. (2023), s. 22-32. ISSN 0021-9797. E-ISSN 1095-7103
Institutional support: RVO:68378271
Keywords : niosomes * static and dynamic light scattering * depolarization * crystalline cholesterol * X-ray diffraction * cryo-TEM
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 9.9, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.jcis.2022.11.008

Niosomes are vesicular carriers formed by a bilayer shell, which is composed of non-ionic surfactants with the addition of a structural supporting agent. Cholesterol is typically used as an additive to increase the stability or drug entrapment efficiency of niosomes. Although increasing the amount of cholesterol is reported to improve niosomal properties, an excessive amount of cholesterol may not be accommodated in the bilayer shell, and thus remain in the crystalline form in the niosomal solution. The presence of a crystalline phase is a potential risk for further medical application. Therefore , Tween 80-based niosomes were prepared using a well-established thin-film hydration method and organic phase injection method, followed by their thorough characterization in order to estimate the cholesterol incorporation into the niosomal shell.
Permanent Link: https://hdl.handle.net/11104/0342045