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Structure-property correlation studies of cross-linked citric acid-based elastomers
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SYSNO ASEP 0567520 Document Type J - Journal Article R&D Document Type O - Ostatní Subsidiary J Ostatní články Title Structure-property correlation studies of cross-linked citric acid-based elastomers Author(s) Koper, F. (PL)
Świergosz, T. (PL)
Zaba, A. (PL)
Flis, A. (PL)
Trávníčková, Martina (FGU-C) RID, ORCID, SAI
Bačáková, Lucie (FGU-C) RID, ORCID
Pamula, E. (PL)
Bogdal, D. (PL)
Kasprzyk, W. (PL)Source Title Engineering of Biomaterials - ISSN 1429-7248
Roč. 24, č. 163 (2021), s. 45-45Number of pages 1 s. Action Conference Biomaterials in Medicine and Veterinary Medicine /30./ Event date 14.10.2021 - 17.10.2021 VEvent location Rytro Country PL - Poland Event type EUR Language eng - English Country PL - Poland Keywords elastomers ; biomaterials ; poly(alkylene citrate) (PAC) biomaterials OECD category Biomaterials (as related to medical implants, devices, sensors) R&D Projects GA21-06065S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support FGU-C - RVO:67985823 Annotation In recent years, poly(alkylene citrate) (PAC) biomaterials have become one of the most promising biomaterials for the production of scaffolds for soft tissue engineering . Moreover, they were considered as components of numerous composites and copolymers studied in a wide range of possible medical applications. In terms of mechanical properties, PAC-based materials are similar to those of human tissues and can be readily tailored to specific needs thus providing the opportunity of being adopted to a variety of bioengineering applications. In addition, cell proliferation studies indicated their remarkable biocompatibility and absence of cytotoxicity, with a significant decrease in thrombogenicity. However, challenging structural characterization of PAC prepolymers has been reported in only a few reports despite the extensive published literature , with the majority of papers showing serious incoherencies in the discussion of the reported spectroscopic results. Hence, the main focus of this work was to optimize the composition and synthesis parameters of PAC polymers based on two diols: 1,6-hexanediol or 1,8-octanediol in two comonomer molar ratios, to obtain materials with defined structure and physicochemical properties. For evaluating their suitability as biomaterials, experiments were performed with adipose tissue-derived stem cells. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2023 Electronic address http://www.biomaterials.pl/Issue-Special%20Issue%20163-2021,10425
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