An Electrochemical Sensor for Detection of Neuroblastoma Markers: Complexation Studies as a Tool for the Selection of a Suitable Receptor for Electrode Coating

Salvadori, Karolína; Páleš, Jakub Marián; Shishkanova, T.V.; Trchová, M.; Fajgar, Radek; Matějka, P.; Cuřínová, Petra

doi:https://dx.doi.org/10.1002/cplu.202200165

Number of the records: 1

An Electrochemical Sensor for Detection of Neuroblastoma Markers: Complexation Studies as a Tool for the Selection of a Suitable Receptor for Electrode Coating

1.

SYSNO ASEP	0559102
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	An Electrochemical Sensor for Detection of Neuroblastoma Markers: Complexation Studies as a Tool for the Selection of a Suitable Receptor for Electrode Coating
Author(s)	Salvadori, Karolína (UCHP-M)_{RID, ORCID, SAI} Páleš, Jakub Marián (UCHP-M) Shishkanova, T.V. (CZ) Trchová, M. (CZ) Fajgar, Radek (UCHP-M)_{RID, ORCID, SAI} Matějka, P. (CZ) Cuřínová, Petra (UCHP-M)_{RID, SAI, ORCID}
Article number	e202200165
Source Title	ChemPlusChem. - : Wiley - ISSN 2192-6506 Roč. 87, č. 8 (2022)
Number of pages	8 s.
Language	eng - English
Country	DE - Germany
Keywords	biosensors ; electropolymerization ; host-guest chemistry ; neuroblastoma markers
OECD category	Analytical chemistry
R&D Projects	GA20-07833S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UCHP-M - RVO:67985858
UT WOS	000837730800001
EID SCOPUS	85135552513
DOI	10.1002/cplu.202200165
Annotation	Homovanillate (HVA) and vanilmandelate (VMA) are recognized markers of diseases, including neuroblastoma. However, their detection in urine represents a challenging task due to the complexity of the matrix. Here, a design, synthesis and thorough investigation of polymerizable urea-based receptors interacting with HVA and VMA are reported. The selection of receptor with the best anion recognition properties for electrode coating is based on 1H NMR and UV-Vis complexation studies. The sensor is prepared by electropolymerization with progress monitoring by cyclic voltammetry. The deposited layer is characterized by IR and scanning electron microscopy. The obtained sensor shows an electrochemical impedance spectroscopy response to VMA with linear range 9.9×10-6 to 1.2×10-3 M and LOD of 3.4x10-6 M. The sensor selectivity was demonstrated by the determination of VMA level in the presence of 16 mM HVA and in artificial urine with and without phosphates, with standard deviations of 0.11, 0.17 and 0.09, respectively.
Workplace	Institute of Chemical Process Fundamentals
Contact	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Year of Publishing	2023
Electronic address	https://hdl.handle.net/11104/0332522

Number of the records: 1