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Cobalt Bis-Dicarbollide Enhances Antibiotics Action towards Staphylococcus epidermidis Planktonic Growth Due to Cell Envelopes Disruption
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SYSNO ASEP 0557551 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cobalt Bis-Dicarbollide Enhances Antibiotics Action towards Staphylococcus epidermidis Planktonic Growth Due to Cell Envelopes Disruption Author(s) Vaňková, E. (CZ)
Lokočová, K. (CZ)
Kašparová, P. (CZ)
Hadravová, Romana (UOCHB-X) RID, ORCID
Křížová, I. (CZ)
Mat’átková, O. (CZ)
Masák, J. (CZ)
Šícha, V. (CZ)Article number 534 Source Title Pharmaceuticals. - : MDPI
Roč. 15, č. 5 (2022)Number of pages 14 s. Language eng - English Country CH - Switzerland Keywords additive effect ; antibiotics ; antimicrobial activity ; carborane ; erythromycin ; gram-positive bacterium ; metallacarboranes ; synergistic effect ; tetracycline ; vancomycin OECD category Microbiology R&D Projects EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 UT WOS 000803417000001 EID SCOPUS 85129745545 DOI 10.3390/ph15050534 Annotation The emergence of antibiotic resistance in opportunistic pathogens represents a huge problem, the solution for which may be a treatment with a combination of multiple antimicrobial agents. Sodium salt of cobalt bis-dicarbollide (COSAN.Na) is one of the very stable, low-toxic, amphiphilic boron-rich sandwich complex heteroboranes. This compound has a wide range of potential applications in the biological sciences due to its antitumor, anti-HIV-1, antimicrobial and antibiofilm activity. Our study confirmed the ability of COSAN.Na (in the concentration range 0.2–2.48 µg/mL) to enhance tetracycline, erythromycin, and vancomycin action towards Staphylococcus epidermidis planktonic growth with an additive or synergistic effect (e.g., the combination of 1.24 µg/mL COSAN.Na and 6.5 µg/mL TET). The effective inhibitory concentration of antibiotics was reduced up to tenfold most efficiently in the case of tetracycline (from 65 to 6.5 µg/mL). In addition, strong effect of COSAN.Na on disruption of the cell envelopes was determined using propidium iodide uptake measurement and further confirmed by transmission electron microscopy. The combination of amphiphilic COSAN.Na with antibiotics can therefore be considered a promising way to overcome antibiotic resistance in Gram-positive cocci. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2023 Electronic address https://doi.org/10.3390/ph15050534
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