Number of the records: 1
Reversed-phase chromatography as an effective tool for the chiral separation of anionic and zwitterionic carboranes using polysaccharide-based chiral selectors
- 1.
SYSNO ASEP 0557516 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Reversed-phase chromatography as an effective tool for the chiral separation of anionic and zwitterionic carboranes using polysaccharide-based chiral selectors Author(s) Horáček, O. (CZ)
Marvalová, J. (CZ)
Štilcová, K. (CZ)
Holub, Josef (UACH-T) SAI, RID, ORCID
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Kučera, R. (CZ)Number of authors 6 Article number 463051 Source Title Journal of Chromatography A. - : Elsevier - ISSN 0021-9673
Roč. 1672, JUN (2022)Number of pages 11 s. Language eng - English Country NL - Netherlands Keywords Boron clusters ; Carboranes ; Chiral separation ; HPLC ; Polysaccharides ; Reversed-phase Subject RIV CA - Inorganic Chemistry OECD category Inorganic and nuclear chemistry R&D Projects GA21-14409S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UACH-T - RVO:61388980 UT WOS 000796517600003 EID SCOPUS 85129322338 DOI 10.1016/j.chroma.2022.463051 Annotation The aspect of the different spatial arrangement of anionic cobalt bis(dicarbollides) and dicarba-nido-undecaboranes remains grossly overlooked despite increased scientific interest. Regarding their growing potential, which does not limit only to medicinal chemistry, suitable enantioseparation methods are needed. The presented paper explores the possibilities of chiral separations of anionic cobalt bis(dicarbollide) and dicarba-7,8-nido-undecaborane derivatives on four polysaccharide-based columns under reversed-phase conditions. The chromatographic behavior of anionic derivatives was evaluated and compared with that of zwitterionic clusters. The isocratic procedure for HPLC method development was suggested. The main parameters for the optimization of separations were described. Successful chiral separations were critically compared to previously reported results in normal phase and polar-organic mode. Reversed-phase separations are superior in resolution, lower consumption of organic solvents, and flexibility during the method development. Moreover, the first chiral discrimination of some hydroxyalkyl derivatives of anionic cobalt bis(dicarbollides) is reported. The outcomes of this work may be used for method development in any area, where the chirality of these interesting molecules is of concern. Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2023 Electronic address https://doi.org/10.1016/j.chroma.2022.463051
Number of the records: 1