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Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise
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SYSNO ASEP 0555719 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise Author(s) Verbrugge, S. (DE)
Alhusen, J. (DE)
Kempin, S. (DE)
Pillon, N. (SE)
Rozman, Jan (UMG-J)
Wackerhage, H. (DE)
Kleinert, M. (DK)Number of authors 7 Source Title Journal of Cellular Biochemistry. - : Wiley - ISSN 0730-2312
Roč. 123, č. 2 (2022), s. 202-214Number of pages 13 s. Publication form Online - E Language eng - English Country US - United States Keywords type-2 diabetes-mellitus ; insulin sensitivity ; glycemic control ; transgenic mice ; overexpression ; increases ; protects ; phosphorylation ; disruption ; metabolism ; exercise metabolism ; glucose uptake ; insulin sensitivity ; insulin signaling ; resistance and endurance exercise ; skeletal muscle OECD category Biochemistry and molecular biology R&D Projects LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000721452700001 DOI 10.1002/jcb.30179 Annotation Exercise improves the insulin sensitivity of glucose uptake in skeletal muscle. Due to that, exercise has become a cornerstone treatment for type 2 diabetes mellitus (T2DM). The mechanisms by which exercise improves skeletal muscle insulin sensitivity are, however, incompletely understood. We conducted a systematic review to identify all genes whose gain or loss of function alters skeletal muscle glucose uptake. We subsequently cross-referenced these genes with recently generated data sets on exercise-induced gene expression and signaling. Our search revealed 176 muscle glucose-uptake genes, meaning that their genetic manipulation altered glucose uptake in skeletal muscle. Notably, exercise regulates the expression or phosphorylation of more than 50% of the glucose-uptake genes or their protein products. This included many genes that previously have not been associated with exercise-induced insulin sensitivity. Interestingly, endurance and resistance exercise triggered some common but mostly unique changes in expression and phosphorylation of glucose-uptake genes or their protein products. Collectively, our work provides a resource of potentially new molecular effectors that play a role in the incompletely understood regulation of muscle insulin sensitivity by exercise. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/jcb.30179
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