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Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics
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SYSNO ASEP 0552875 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics Author(s) Gajdošová, Veronika (UMCH-V) RID, ORCID
Strachota, Beata (UMCH-V) RID
Strachota, Adam (UMCH-V) RID, ORCID
Michálková, Danuše (UMCH-V)
Krejčíková, Sabina (UMCH-V)
Fulín, P. (CZ)
Nyč, O. (CZ)
Břínek, A. (CZ)
Zemek, M. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCIDArticle number 1101 Source Title Materials. - : MDPI
Roč. 15, č. 3 (2022)Number of pages 22 s. Language eng - English Country CH - Switzerland Keywords thermoplastic starch ; poly(ε-caprolactone) ; polymer blends Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects TN01000008 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) NU21-06-00084 GA MZd - Ministry of Health (MZ) GA19-04925S GA ČR - Czech Science Foundation (CSF) Research Infrastructure CzechNanoLab - 90110 - Vysoké učení technické v Brně Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000760870800001 EID SCOPUS 85123610917 DOI 10.3390/ma15031101 Annotation We report a reproducible preparation and characterization of highly homogeneous thermoplastic starch/pol(ε‑caprolactone) blends (TPS/PCL) with a minimal thermomechanical degradation and co-continuous morphology. These materials would be suitable for biomedical applications, specifically for the local release of antibiotics (ATB) from the TPS phase. The TPS/PCL blends were prepared in the whole concentration range. In agreement with theoretical predictions based on component viscosities, the co-continuous morphology was found for TPS/PCL blends with a composition of 70/30 wt.%. The minimal thermomechanical degradation of the blends was achieved by an optimization of the processing conditions and by keeping processing temperatures as low as possible, because higher temperatures might damage ATB in the final application. The blends’ homogeneity was verified by scanning electron microscopy. The co-continuous morphology was confirmed by submicron-computed tomography. The mechanical performance of the blends was characterized in both microscale (by an instrumented microindentation hardness testing, MHI) and macroscale (by dynamic thermomechanical analysis, DMTA). The elastic moduli of TPS increased ca four times in the TPS/PCL (70/30) blend. The correlations between elastic moduli measured by MHI and DMTA were very strong, which implied that, in the future studies, it would be possible to use just micromechanical testing that does not require large specimens. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://www.mdpi.com/1996-1944/15/3/1101
Number of the records: 1