The anti-depressive effects of ultra-high static magnetic field

0552056 - FZÚ 2023 RIV US eng J - Journal Article
Lv, Y. - Fan, Y. - Tian, X. - Yu, B. - Song, C. - Feng, C. - Zhang, L. - Ji, X. - Zablotskii, Vitalii - Zhang, X.
The anti-depressive effects of ultra-high static magnetic field.
Journal of Magnetic Resonance Imaging. Roč. 56, č. 2 (2022), s. 354-365. ISSN 1053-1807. E-ISSN 1522-2586
Institutional support: RVO:68378271
Keywords : ultra-high field magnetic resonance imaging * static magnetic field * safety * depression * behavioral tests
OECD category: Particles and field physics
Impact factor: 4.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/jmri.28035

Compared to the sham group, healthy C57/6 mice spent more time in the center area (35.12 ± 4.034, increased by 47.19%) in open field test and improved novel index (0.6201 ± 0.02522, increased by 16.76%) in three-chambered social test a few weeks after 1 hour 11.1–33.0 T SMF exposure. 7 T SMF exposure for 8 hours alleviated the depression state of depression mice, including less immobile time in tail suspension test (58.32% reduction) and higher sucrose preference (increased by 8.80%). Brain tissue analysis shows that 11.1–33.0 T and 7 T SMFs can increase oxytocin by 164.65% and 36.03%, respectively. Moreover, the c-Fos level in hippocampus region was increased by 14.79%. 11.1–33.0 T SMFs exposure for 1 hour or 7 T SMF exposure for 8 hours did not have detrimental effects on healthy or depressed mice. Instead, these ultra-high field SMFs have anti-depressive potentials.
Permanent Link: https://hdl.handle.net/11104/0333047