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Age-related changes in the temporal processing of acoustical signals in the auditory cortex of rats
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SYSNO ASEP 0551379 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Age-related changes in the temporal processing of acoustical signals in the auditory cortex of rats Author(s) Bureš, Zbyněk (UEM-P) RID, ORCID
Pysaněnko, Kateryna (UEM-P) ORCID
Syka, Josef (UEM-P) RIDArticle number 108025 Source Title Hearing Research. - : Elsevier - ISSN 0378-5955
Roč. 402, SI (2021)Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords auditory system ; aging ; temporal processing ; rate code ; synchronization Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects GA18-09692S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000623054500011 EID SCOPUS 85088213828 DOI 10.1016/j.heares.2020.108025 Annotation Age-related hearing loss is manifested primarily by a decreased sensitivity to faint sounds, that is, by elevation of the hearing thresholds. Nevertheless, aging also affects the ability of the auditory system to process temporal parameters of the sound stimulus. To explore the precision and reliability of auditory temporal processing during aging, responses to several types of sound stimuli were recorded from neurons of the auditory cortex (AC) of young and aged anaesthetized Fischer 344 rats. In response to broad-band noise bursts, the aged rats exhibited larger response magnitudes, a higher proportion of monotonic units, and also a larger variability of response magnitudes, suggesting a lower stability of the rate code. Of primary interest were the responses to temporally structured stimuli (amplitude -modulated (AM) noise, frequency-modulated (FM) tones, and click trains) recorded separately in the right and left AC. Significant differences of temporal processing were already found between the neuronal responses in the left and right AC in the young animals: for the click trains, the left hemisphere exhibited a greater responsiveness to higher repetition rates, lower vector strength values, and a lower similarity of responses. The two hemispheres were also affected differently by aging. In the right hemisphere, neurons in the aged animals displayed worse synchronization with the AM noise and clicks, but better synchronization with the FM tone. In the left hemisphere, neuronal synchronization with the stimulus modulation improved at a higher age for all three stimuli. The results show that the ability of the aging auditory system to process temporal parameters of the stimulus strongly depends on the stimulus type and on laterality. Furthermore, the commonly reported age-related decline in the temporal processing ability cannot be regarded as general as, at least at the neuronal level in the AC, objective measures of the temporal representation often exhibit age-related improvement instead of deterioration. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S0378595520302963?via%3Dihub
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