Thermo- and ROS-responsive self-assembled polymer nanoparticle tracers for 19F MRI theranostics

Kolouchová, Kristýna; Groborz, Ondřej; Černochová, Zulfiya; Škarková, A.; Brabek, J.; Rosel, D.; Švec, Pavel; Starčuk, Zenon; Šlouf, Miroslav; Hrubý, Martin

doi:https://dx.doi.org/10.1021/acs.biomac.0c01316

Number of the records: 1

Thermo- and ROS-responsive self-assembled polymer nanoparticle tracers for 19F MRI theranostics

1.

SYSNO ASEP	0543182
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Thermo- and ROS-responsive self-assembled polymer nanoparticle tracers for 19F MRI theranostics
Author(s)	Kolouchová, Kristýna (UMCH-V)_{ORCID, RID} Groborz, Ondřej (UMCH-V)_{ORCID, RID} Černochová, Zulfiya (UMCH-V)_{RID, ORCID} Škarková, A. (CZ) Brabek, J. (CZ) Rosel, D. (CZ) Švec, Pavel (UMCH-V)_{RID, ORCID} Starčuk, Zenon (UPT-D)_RID Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	Biomacromolecules. - : American Chemical Society - ISSN 1525-7797 Roč. 22, č. 6 (2021), s. 2325-2337
Number of pages	13 s.
Language	eng - English
Country	US - United States
Keywords	thermoresponsivity ; redox responsivity ; reactive oxygen species
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Subject RIV - cooperation	Institute of Scientific Instruments - Medical Facilities ; Equipment
R&D Projects	LTC19032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2018133 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA19-01438S GA ČR - Czech Science Foundation (CSF)
	LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Research Infrastructure	EATRIS-CZ III - 90133 - Univerzita Palackého v Olomouci Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013 ; UPT-D - RVO:68081731
UT WOS	000662267600002
EID SCOPUS	85106443904
DOI	10.1021/acs.biomac.0c01316
Annotation	Fluorine-19 magnetic resonance imaging (19F MRI) enables detailed in vivo tracking of fluorine-containing tracers and is therefore becoming a particularly useful tool in noninvasive medical imaging. In previous studies, we introduced biocompatible polymers based on the hydrophilic monomer N-(2-hydroxypropyl)methacrylamide (HPMA) and the thermoresponsive monomer N-(2,2-difluoroethyl)acrylamide (DFEA). These polymers have abundant magnetically equivalent fluorine atoms and advantageous properties as 19F MRI tracers. Furthermore, in this pilot study, we modified these polymers by introducing a redox-responsive monomer. As a result, our polymers changed their physicochemical properties once exposed to an oxidative environment. Reactive oxygen species (ROS)-responsive polymers were prepared by incorporating small amounts (0.9–4.5 mol %) of the N-[2-(ferrocenylcarboxamido)ethyl]acrylamide (FcCEA) monomer, which is hydrophobic and diamagnetic in the reduced electroneutral (Fe(II), ferrocene) state but hydrophilic and paramagnetic in the oxidized (Fe(III), ferrocenium cation) state. This property can be useful for theranostic purposes (therapy and diagnostic purposes), especially, in terms of ROS-responsive drug-delivery systems. In the reduced state, these nanoparticles remain self-assembled with the encapsulated drug but release the drug upon oxidation in ROS-rich tumors or inflamed tissues.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2022
Electronic address	https://pubs.acs.org/doi/10.1021/acs.biomac.0c01316

Number of the records: 1