Number of the records: 1
Voltammetric sensing of glycans modified by osmium(VI)ligand complexes. The influence of N-acetyl neuraminic acid
- 1.
SYSNO ASEP 0541880 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Voltammetric sensing of glycans modified by osmium(VI)ligand complexes. The influence of N-acetyl neuraminic acid Author(s) Trefulka, Mojmír (BFU-R) RID, ORCID
Černocká, Hana (BFU-R) RID, ORCID
Havran, Luděk (BFU-R) RID, ORCID
Hasoň, Stanislav (BFU-R) RID, ORCID
Fojt, Lukáš (BFU-R) RID, ORCID
Ostatná, Veronika (BFU-R) RID, ORCIDNumber of authors 6 Article number 137658 Source Title Electrochimica acta. - : Elsevier - ISSN 0013-4686
Roč. 369, č. 2021 (2021)Number of pages 8 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords aberrant sialylation ; cancer ; osmium ; glycosylation ; proteins Subject RIV CG - Electrochemistry OECD category Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis) R&D Projects GA18-18154S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000612048600016 EID SCOPUS 85098849453 DOI 10.1016/j.electacta.2020.137658 Annotation A quick and simple way of glycan analysis is combining glycans modification by sixvalent osmium complexes with nitrogenous ligands, particularly with N,N,N,N-tetramethylethylenediamine (Os(VI)tem) and their voltammetric analysis. Os(VI)tem-modified oligosaccharides are reduced at the mercury electrode yielding peaks I-III, representing reduction steps of Os(VI) oxocomplexes. In this work we clarified the individual reduction steps and showed analytical applications for Os(VI)tem modified glycans, including distinguishing sialoglycan regioisomer type or discriminating glycans according to the sialic acid content. Presence or absence of sialic acid was tested in complex glycans as well as in glycoproteins. (C) 2020 Elsevier Ltd. All rights reserved. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S001346862032051X?via%3Dihub
Number of the records: 1