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Comparative analysis of the midgut microbiota of two natural tick vectors of Rickettsia rickettsii
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SYSNO ASEP 0540933 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Comparative analysis of the midgut microbiota of two natural tick vectors of Rickettsia rickettsii Author(s) Pavanelo, D.B. (BR)
Schroder, N.C.H. (BR)
Pin Viso, N.D. (AR)
Martins, Larissa Almeida (BC-A) RID, ORCID
Malossi, C.D. (BR)
Galletti, M.F.B.M. (BR)
Labruna, M. B. (BR)
Daffre, S. (BR)
Farber, M. (AR)
Fogaca, A.C. (BR)Number of authors 10 Article number 103606 Source Title Developmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X
Roč. 106, May 106 (2020)Number of pages 5 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords amblyomma-aureolatum ; spotted-fever ; protease inhibitor ; cajennense ; infection ; symbiont ; disease ; Host-microbe interaction ; Microbiota ; Midgut ; Rickettsiae ; Tick ; Vector competence Subject RIV EC - Immunology OECD category Immunology Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000517853000001 EID SCOPUS 85077375229 DOI 10.1016/j.dci.2019.103606 Annotation Although the ticks Amblyomma sculptum and Amblyomma aureolatum are important vectors of Rickettsia rickettsii, causative agent of the life-threatening Rocky Mountain spotted fever, A. aureolatum is considerably more susceptible to infection than A. sculptum. As the microbiota can interfere with the colonization of arthropod midgut (MG) by pathogens, in the current study we analyzed the MG microbiota of both tick species. Our results revealed that the MG of A. aureolatum harbors a prominent microbiota, while A. sculptum does not. Remarkably, a significant reduction of the bacterial load was recorded in R. rickettsii-infected A. aureolatum. In addition, the taxonomy analysis of the MG bacterial community of A. aureolatum revealed a dominance of the genus Francisella, suggesting an endosymbiosis. This study is the first step in getting insights into the mechanisms underlying the interactions among Amblyomma species, their microbiota and R. rickettsii. Additional studies to better understand these mechanisms are required and may help the development of novel alternatives to block rickettsial transmission. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0145305X19305178?via%3Dihub
Number of the records: 1