Number of the records: 1
Mannan-based nanodiagnostic agents for targeting sentinel lymph nodes and tumors
- 1.
SYSNO ASEP 0536794 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mannan-based nanodiagnostic agents for targeting sentinel lymph nodes and tumors Author(s) Jirátová, M. (CZ)
Gálisová, A. (CZ)
Rabyk, Mariia (UMCH-V) RID, ORCID
Sticová, E. (CZ)
Hrubý, Martin (UMCH-V) RID, ORCID
Jirák, D. (CZ)Article number 146 Source Title Molecules. - : MDPI
Roč. 26, č. 1 (2021)Number of pages 16 s. Language eng - English Country CH - Switzerland Keywords mannan ; SLN ; cancer Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects NV16-30544A GA MZd - Ministry of Health (MZ) GA18-07983S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000606243900001 EID SCOPUS 85099332057 DOI 10.3390/molecules26010146 Annotation Early detection of metastasis is crucial for successful cancer treatment. Sentinel lymph node (SLN) biopsies are used to detect possible pathways of metastasis spread. We present a unique non-invasive diagnostic alternative to biopsy along with an intraoperative imaging tool for surgery proven on an in vivo animal tumor model. Our approach is based on mannan-based copolymers synergistically targeting: (1) SLNs and macrophage-infiltrated solid tumor areas via the high-affinity DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) receptors and (2) tumors via the enhanced permeability and retention (EPR) effect. The polymer conjugates were modified with the imaging probes for visualization with magnetic resonance (MR) and fluorescence imaging, respectively, and with poly(2-methyl-2-oxazoline) (POX) to lower unwanted accumulation in internal organs and to slow down the biodegradation rate. We demonstrated that these polymer conjugates were successfully accumulated in tumors, SLNs and other lymph nodes. Modification with POX resulted in lower accumulation not only in internal organs, but also in lymph nodes and tumors. Importantly, we have shown that mannan-based polymer carriers are non-toxic and, when applied to an in vivo murine cancer model, and offer promising potential as the versatile imaging agents. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://www.mdpi.com/1420-3049/26/1/146
Number of the records: 1