Translational Research in Serious Human Diseases

0536626 - ÚŽFG 2021 RIV CZ eng M - Monography Chapter
Komrsková, Anna - Drutovič, Dávid
The role of protein kinases during mammalian oocyte meiosis.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 244-250. ISBN 978-80-200-3158-7
R&D Projects: GA MŠMT(CZ) LO1609; GA MŠMT(CZ) LTAUSA17097
Institutional support: RVO:67985904
Keywords : oocyte * spindle * Aurora kinases
OECD category: Developmental biology

Proper formation of the spindle during the first meiotic division is crucial for correct chromosome segregation and formation of a functional oocyte. Aurora kinases and Polo-like kinases are involved in the mechanisms regulating proper spindle assembly. Both types of these kinases have their specific role to play independently and in cooperation. If anything goes wrong in meiotic spindle assembly, it can lead to infertility or birth defects, as incorrect chromosome segregation causes aneuploidies. Some of these defective chromosome segregations are incompatible with life, some cause birth defects such as Down´s syndrome. Humans are especially prone to these aneuploidies, making the research of Aurora kinases and Polo-like kinases particularly appealing.
Permanent Link: http://hdl.handle.net/11104/0314372