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Enantiorecognition ability of different chiral selectors for separation of liquid crystals in supercritical fluid chromatography, critical evaluation
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SYSNO ASEP 0534674 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Enantiorecognition ability of different chiral selectors for separation of liquid crystals in supercritical fluid chromatography, critical evaluation Author(s) Vaňkátová, Petra (FZU-D) ORCID, RID
Folprechtová, D. (CZ)
Kalíková, K. (CZ)
Kubíčková, A. (CZ)
Armstrong, D.W. (US)
Tesařová, E. (CZ)Number of authors 6 Article number 461138 Source Title Journal of Chromatography A. - : Elsevier - ISSN 0021-9673
Roč. 1622, July (2020), s. 1-8Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords supercritical fluid chromatography ; chiral stationary phases ; liquid crystals ; enantioseparation ; additives Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry R&D Projects EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 000536132400031 EID SCOPUS 85084121926 DOI 10.1016/j.chroma.2020.461138 Annotation Comprehensive study of enantioselective potential of eight different chiral stationary phases for chiral liquid crystal-forming molecules was conducted. The tested columns were: (i) polysaccharide-based Trefoil AMY1, CEL1 and CEL2 and (ii) superficially porous particles packed TeicoShell, VancoShell, TagShell, DMP-MaltoShell, and NicoShell. Twenty racemic mixtures of rod-like liquid crystalline materials comprising three different types of chiral centres and various other structural differences were used. Mobile phases consisting of supercritical carbon dioxide and alcohol as cosolvent were used. Effect of acidic and/or basic additives on enantioselectivity was also evaluated. Chiral stationary phases based on polysaccharides were found to have the greatest enantioselective potential for rod-like molecules that form liquid crystals, followed by TeicoShell, which proved suitable for enantioseparation of non-halogenated liquid crystals with lactic acid-based chiral centre.
Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2021 Electronic address https://doi.org/10.1016/j.chroma.2020.461138
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