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Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry
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SYSNO ASEP 0532026 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry Author(s) Radoňová, Lenka (UZFG-Y)
Pauerová, Tereza (UZFG-Y)
Jansová, Denisa (UZFG-Y) ORCID
Danadová, J. (CZ)
Škultéty, Michal (UZFG-Y) ORCID
Kubelka, Michal (UZFG-Y) RID, ORCID
Anger, Martin (UZFG-Y) ORCIDArticle number 7455 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 10, č. 1 (2020)Number of pages 12 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords cyclins ; meiosis Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA19-24528S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UZFG-Y - RVO:67985904 UT WOS 000560030700001 EID SCOPUS 85084242815 DOI 10.1038/s41598-020-64418-1 Annotation In several species, including Xenopus, mouse and human, two members of cyclin A family were identified. Cyclin A2, which is ubiquitously expressed in dividing cells and plays role in DNA replication, entry into mitosis and spindle assembly, and cyclin A1, whose function is less clear and which is expressed in spermatocytes, leukemia cells and in postmitotic multiciliated cells. Deletion of the gene showed that cyclin A1 is essential for male meiosis, but nonessential for female meiosis. Our results revealed, that the cyclin A1 is not only dispensable in oocytes, we show here that its expression is in fact undesirable in these cells. Our data demonstrate that the APC/C and proteasome in oocytes are unable to target sufficiently cyclin A1 before anaphase, which leads into anaphase arrest and direct inhibition of separase. The cyclin A1-induced cell cycle arrest is oocyte-specific and the presence of cyclin A1 in early embryos has no effect on cell cycle progression or chromosome division. Cyclin A1 is therefore not only an important cell cycle regulator with biased expression in germline, being essential for male and damaging for female meiosis, its persistent expression during anaphase in oocytes shows fundamental differences between APC/C function in oocytes and in early embryos. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2021 Electronic address https://www.nature.com/articles/s41598-020-64418-1
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