Number of the records: 1
Implant-forming polymeric 19F MRI-tracer with tunable dissolution
- 1.
SYSNO ASEP 0531966 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Implant-forming polymeric 19F MRI-tracer with tunable dissolution Author(s) Kolouchouvá, K. (CZ)
Jirák, D. (CZ)
Groborz, Ondřej (UOCHB-X) ORCID, RID
Sedláček, O. (CZ)
Ziolkowska, N. (CZ)
Vít, M. (CZ)
Sticová, E. (CZ)
Gálisová, A. (CZ)
Švec, P. (CZ)
Trousil, J. (CZ)
Hájek, M. (CZ)
Hrubý, M. (CZ)Source Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 327, Nov 10 (2020), s. 50-60Number of pages 11 s. Language eng - English Country NL - Netherlands Keywords polymer implant ; 19F magnetic resonance imaging ; double-stimuli responsivity ; tunable dissolution Subject RIV CC - Organic Chemistry OECD category Organic chemistry Method of publishing Limited access Institutional support UOCHB-X - RVO:61388963 UT WOS 000585933700006 EID SCOPUS 85089267901 DOI 10.1016/j.jconrel.2020.07.026 Annotation Magnetic resonance imaging (MRI) using 19F-based tracers has emerged as a promising multi-purpose noninvasive diagnostic tool and its application requires the use of various 19F-based tracers for the intended diagnostic purpose. In this study, we report a series of double-stimuli-responsive polymers for use as injectable implants, which were designed to form implants under physiological conditions, and to subsequently dissolve with different dissolution rates (t1/2 ranges from 30 to more than 250 days). Our polymers contain a high concentration of fluorine atoms, providing remarkable signal detectability, and both a hydrophilic monomer and a pH-responsive monomer that alter the biodistribution properties of the implant. The implant location and dissolution were observed using 19F MRI, which allows the anatomic extent of the implant to be monitored. The dissolution kinetics and biocompatibility of these materials were thoroughly analyzed. No sign of toxicity in vitro or in vivo or pathology in vivo was observed, even in chronic administration. The clinical applicability of our polymers was further confirmed via imaging of a rat model by employing an instrument currently used in human medicine. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2021 Electronic address https://doi.org/10.1016/j.jconrel.2020.07.026
Number of the records: 1