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Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease
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SYSNO ASEP 0511376 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease Author(s) Arab, A. (CZ)
Rudá-Kučerová, J. (CZ)
Minsterová, A. (CZ)
Dražanová, Eva (UPT-D) RID, ORCID, SAI
Szabó, N. (CZ)
Starčuk jr., Zenon (UPT-D) RID, ORCID, SAI
Rektorová, I. (CZ)
Khairnar, A. (CZ)Number of authors 8 Source Title Neurotoxicity Research. - : Springer - ISSN 1029-8428
Roč. 36, č. 4 (2019), s. 724-735Number of pages 11 s. Publication form Print - P Language eng - English Country US - United States Keywords behaviour ; diffusion kurtosis imaging ; methamphetamine ; mice ; MRI ; Parkinson's disease ; tract-based spatial statistics Subject RIV FS - Medical Facilities ; Equipment OECD category Neurosciences (including psychophysiology R&D Projects EF16_013/0001775 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED0017/01/01 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UPT-D - RVO:68081731 UT WOS 000494483100008 EID SCOPUS 85068093220 DOI 10.1007/s12640-019-00068-0 Annotation Methamphetamine (METH) abuse is known to increase the risk of Parkinson's disease (PD) due to its dopaminergic neurotoxicity. This is the rationale for the METH model of PD developed by toxic METH dosing (10 mg/kg four times every 2 h) which features robust neurodegeneration and typical motor impairment in mice. In this study, we used diffusion kurtosis imaging to reveal microstructural brain changes caused by METH-induced neurodegeneration. The METH-treated mice and saline-treated controls underwent diffusion kurtosis imaging scanning using the Bruker Avance 9.4 Tesla MRI system at two time-points: 5 days and 1 month to capture both early and late changes induced by METH. At 5 days, we found a decrease in kurtosis in substantia nigra, striatum and sensorimotor cortex, which is likely to indicate loss of DAergic neurons. At 1 month, we found an increase of kurtosis in striatum and sensorimotor cortex and hippocampus, which may reflect certain recovery processes. Furthermore, we performed tract-based spatial statistics analysis in the white matter and at 1 month, we observed increased kurtosis in ventral nucleus of the lateral lemniscus and some of the lateral thalamic nuclei. No changes were present at the early stage. This study confirms the ability of diffusion kurtosis imaging to detect microstructural pathological processes in both grey and white matter in the METH model of PD. The exact mechanisms underlying the kurtosis changes remain to be elucidated but kurtosis seems to be a valuable biomarker for tracking microstructural brain changes in PD and potentially other neurodegenerative disorders. Workplace Institute of Scientific Instruments Contact Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Year of Publishing 2020 Electronic address https://link.springer.com/article/10.1007%2Fs12640-019-00068-0
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