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Degradation of biologically active substances by vapor-phase hydrogen peroxide
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SYSNO ASEP 0506883 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Degradation of biologically active substances by vapor-phase hydrogen peroxide Author(s) Švrček, J. (CZ)
Syslová, K. (CZ)
Stíbal, D. (CZ)
Kuzma, Marek (MBU-M) ORCID, RID
Kačer, P. (CZ)Source Title Research on Chemical Intermediates. - : Springer - ISSN 0922-6168
Roč. 40, č. 2 (2014), s. 619-626Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords Vapor-phase hydrogen peroxide ; Pharmaceutical drugs ; Decontamination Subject RIV EE - Microbiology, Virology OECD category Microbiology Method of publishing Limited access Institutional support MBU-M - RVO:61388971 UT WOS 000329796200013 EID SCOPUS 84895056733 DOI 10.1007/s11164-012-0987-x Annotation We have examined the potential of vapor-phase hydrogen peroxide (VPHP) for degradation of 21 structurally different pharmaceutical substances. Our results show that VPHP can be used to degrade pharmaceuticals, but it was not universally applicable to all the drugs tested. Structural analysis revealed a significant correlation of the molecular structure of a compound with its susceptibility to VPHP. Tertiary amino groups seem to be the initiation centers, although the overall susceptibility of a substance depends on other factors also. Several tested substances underwent significant structural changes, suggesting a possible decrease in their biological activity. As far as we are aware, this is one of the first reports of application of VPHP to the decontamination of hazardous chemicals. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2020 Electronic address https://link.springer.com/article/10.1007%2Fs11164-012-0987-x
Number of the records: 1