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Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female rats
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SYSNO ASEP 0504094 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female rats Author(s) Egan Beňová, T. (SK)
Viczenczová, C. (SK)
Szeiffová Bačová, B. (SK)
Knezl, V. (SK)
Dosenko, V. (UA)
Rauchová, Hana (FGU-C) RID, ORCID
Zeman, M. (SK)
Reiter, R. J. (US)
Tribulová, N. (SK)Source Title Molecular and Cellular Biochemistry. - : Springer - ISSN 0300-8177
Roč. 454, 1-2 (2019), s. 191-202Number of pages 12 s. Language eng - English Country US - United States Keywords female rats ; sucrose diet ; adiposity ; cardiac connexin-43 ; ventricular fibrillation ; melatonin ; Omega-3 PUFA Subject RIV ED - Physiology OECD category Physiology (including cytology) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000461046100017 EID SCOPUS 85056615215 DOI 10.1007/s11010-018-3463-0 Annotation We aimed to explore whether specific high-sucrose intake in older female rats affects myocardial electrical coupling protein, connexin-43 (Cx43), protein kinase C (PKC) signaling, miR-1 and miR-30a expression, and susceptibility of the heart to malignant arrhythmias. Possible benefit of the supplementation with melatonin (40 mu g/ml/day) and omega-3 polyunsaturated fatty acids (Omacor, 25g/kg of rat chow) was examined as well. Results have shown that 8weeks lasting intake of 30% sucrose solution increased serum cholesterol, triglycerides, body weight, heart weight, and retroperitoneal adipose tissues. It was accompanied by downregulation of cardiac Cx43 and PKC epsilon signaling along with an upregulation of myocardial PKC and miR-30a rendering the heart prone to ventricular arrhythmias. There was a clear benefit of melatonin or omega-3 PUFA supplementation due to their antiarrhythmic effects associated with the attenuation of myocardial Cx43, PKC, and miR-30a abnormalities as well as adiposity. The potential impact of these findings may be considerable, and suggests that high-sucrose intake impairs myocardial signaling mediated by Cx43 and PKC contributing to increased susceptibility of the older obese female rat hearts to malignant arrhythmias. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2020 Electronic address https://link.springer.com/article/10.1007%2Fs11010-018-3463-0
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