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The ESC Textbook of Cardiovascular Development
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SYSNO ASEP 0499945 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Developmental aspects of cardiac arrhythmias Author(s) Postma, A. V. (NL)
Sedmera, David (FGU-C) RID, ORCID, SAI
Vostárek, František (FGU-C) RID, ORCID, SAI
Christoffels, V. M. (NL)
Bezzina, C. R. (NL)Source Title The ESC Textbook of Cardiovascular Development. - Oxford : Oxford University Press, 2018 / Pérez-Pomares José M. ; Kelly Robert - ISBN 9780198757269 Pages s. 269-282 Number of pages 14 s. Number of pages 384 Publication form Print - P Language eng - English Country GB - United Kingdom Keywords arrhythmia ; develompent ; heart ; ECG ; transcription factors ; conduction system Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery OECD category Cardiac and Cardiovascular systems R&D Projects GAP302/11/1308 GA ČR - Czech Science Foundation (CSF) GA13-12412S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 DOI 10.1093/med/9780198757269.003.0027 Annotation The rhythmic and synchronized contraction of atria and ventricles is essential for efficient pumping of blood throughout the body. This process relies on the proper generation and conduction of the cardiac electrical impulse. Electrophysiological properties differ in various regions of the heart, revealing intrinsic heterogeneities rooted, at least in part, in regional differences in expression of ion channel and gap junction subunit genes. A causal relation between transcription factors and such regionalized gene expression has been established. Abnormal cardiac electrical function and arrhythmias in the postnatal heart may stem from a developmental changes in gene regulation. Genome-wide association studies have provided strong evidence that common genetic variation at developmental gene loci modulates electrocardiographic indices of conduction and repolarization and susceptibility to arrhythmia. Functional aspects are illustrated by description of selected prenatally occurring arrhythmias and their possible mechanisms. We also discuss recent findings and provide background insight into these complex mechanisms. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2019
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