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Serine proteases in schistosomes and other trematodes
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SYSNO ASEP 0490315 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Serine proteases in schistosomes and other trematodes Author(s) Dvorak, J. (CZ)
Horn, Martin (UOCHB-X) RID, ORCIDSource Title International Journal for Parasitology. - : Elsevier - ISSN 0020-7519
Roč. 48, č. 5 (2018), s. 333-344Number of pages 12 s. Language eng - English Country AU - Australia Keywords proteolytic enzyme ; serine protease ; peptidase ; Trematoda ; Platyhelminthes ; Schistosoma ; fluke Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects LD15101 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1302 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 UT WOS 000430889100003 EID SCOPUS 85042653239 DOI 10.1016/j.ijpara.2018.01.001 Annotation Trematodes, also known as flukes, are phylogenetically ancient parasitic organisms. Due to their importance as human and veterinary parasites, their proteins have been investigated extensively as drug and vaccine targets. Among those, proteases, as crucial enzymes for parasite survival, are considered candidate molecules for anti-parasitic interventions. Surprisingly however, trematode serine proteases, in comparison with other groups of proteases, are largely neglected. Genes encoding serine proteases have been identified in trematode genomes in significant abundance, but the biological roles and biochemical functions of these proteases are poorly understood. However, increasing volumes of genomic and proteomic studies, and accumulated experimental evidence, indicate that this class of proteases plays a substantial role in host-parasite interactions and parasite survival. Here, we discuss in detail serine proteases at genomic and protein levels, and their known or hypothetical functions. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2019
Number of the records: 1