Nanostructure of hyaluronan acyl-derivatives in the solid state

Chmelař, J.; Bělský, P.; Mrázek, J.; Švadlák, D.; Hermannová, M.; Šlouf, Miroslav; Krakovský, I.; Šmejkalová, D.; Velebný, V.

doi:https://dx.doi.org/10.1016/j.carbpol.2018.04.111

Number of the records: 1

Nanostructure of hyaluronan acyl-derivatives in the solid state

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SYSNO ASEP	0489374
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Nanostructure of hyaluronan acyl-derivatives in the solid state
Author(s)	Chmelař, J. (CZ) Bělský, P. (CZ) Mrázek, J. (CZ) Švadlák, D. (CZ) Hermannová, M. (CZ) Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Krakovský, I. (CZ) Šmejkalová, D. (CZ) Velebný, V. (CZ)
Source Title	Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617 Roč. 195, 1 September (2018), s. 468-475
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	hyaluronan ; hydrophobization ; nanostructure
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
Institutional support	UMCH-V - RVO:61389013
UT WOS	000433204900053
EID SCOPUS	85046735008
DOI	10.1016/j.carbpol.2018.04.111
Annotation	Acyl derivatives of hyaluronan (acyl-HA) are promising materials for biomedical applications. Depending on the acyl length and the degree of substitution, these derivatives range from self-assembling water-soluble polymers to materials insoluble in aqueous environments. The behaviour of acyl-HA was studied in solution, but little attention was paid to the solid state, despite its importance for applications such as medical device fabrication. We thus used X-ray scattering and electron microscopy to explore the solid-state nano-structure of acyl-HA. The set of samples included various substituents, substitution degrees and molecular weights. The obtained data showed that all studied acyl-HA materials contained structures with dimensions on the order of nanometres that were not present in unmodified HA. The size of the nanostructures increased with the acyl length, while the degree of substitution and molecular weight had negligible effects. We suggest that the observed nanostructure corresponds to a distribution of hydrophobic domains in a hydrophilic matrix of unmodified HA segments.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2019

Number of the records: 1