Number of the records: 1
Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production
- 1.
SYSNO ASEP 0488741 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production Author(s) Matsuura, H. N. (BR)
Malik, S. (CZ)
de Costa, F. (BR)
Yousefzadi, M. (IR)
Mirjalili, M. H. (IR)
Arroo, R.R.J. (GB)
Bhambra, A.S. (GB)
Strnad, Miroslav (UEB-Q) RID, ORCID
Bonfill, M. (ES)
Fett-Neto, A. G. (BR)Number of authors 10 Source Title Molecular Biotechnology. - : Springer - ISSN 1073-6085
Roč. 60, č. 2 (2018), s. 169-183Number of pages 15 s. Language eng - English Country US - United States Keywords Genetically engineered cultures ; In vitro culture ; Natural products ; Secondary metabolites ; Synthetic biology Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology Institutional support UEB-Q - RVO:61389030 UT WOS 000424251300009 EID SCOPUS 85039740792 DOI 10.1007/s12033-017-0056-1 Annotation Plant secondary metabolism evolved in the context of highly organized and differentiated cells and tissues, featuring massive chemical complexity operating under tight environmental, developmental and genetic control. Biotechnological demand for natural products has been continuously increasing because of their significant value and new applications, mainly as pharmaceuticals. Aseptic production systems of plant secondary metabolites have improved considerably, constituting an attractive tool for increased, stable and large-scale supply of valuable molecules. Surprisingly, to date, only a few examples including taxol, shikonin, berberine and artemisinin have emerged as success cases of commercial production using this strategy. The present review focuses on the main characteristics of plant specialized metabolism and their implications for current strategies used to produce secondary compounds in axenic cultivation systems. The search for consonance between plant secondary metabolism unique features and various in vitro culture systems, including cell, tissue, organ, and engineered cultures, as well as heterologous expression in microbial platforms, is discussed. Data to date strongly suggest that attaining full potential of these biotechnology production strategies requires being able to take advantage of plant specialized metabolism singularities for improved target molecule yields and for bypassing inherent difficulties in its rational manipulation. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2019
Number of the records: 1