Ontogenetic Development of Sensitivity of the Cerebral Cortex to an Antagonist of GABA(A) Receptor Bicuculline

0488630 - FGÚ 2018 RIV CZ eng J - Journal Article
Mareš, Pavel - Bernášková, Klára - Kubová, Hana
Ontogenetic Development of Sensitivity of the Cerebral Cortex to an Antagonist of GABA(A) Receptor Bicuculline.
Physiological Research. Roč. 67, č. 1 (2018), s. 149-153. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LH15032
Institutional support: RVO:67985823
Keywords : cerebral cortex * rat * postnatal development * epileptic phenomena * bicuculline
OECD category: Neurosciences (including psychophysiology
Impact factor: 1.701, year: 2018

Local application of four concentrations of bicuculline methiodide (a specific antagonist of GABA(A) receptors) was used to study a sensitivity of somatosensory cortex in four age groups of immature rats with implanted electrodes. Presence and latencies of two epileptic phenomena (focal discharges and seizures) were evaluated. Focal discharges exhibited moderate tendency to a decrease of sensitivity to bicuculline methiodide with maturation. Concentration-effect relation of incidence of focal discharges was observed only in 7- and 12-day-old but not in older animals. Results with incidence and latencies of seizures did not show relations to age or concentration of bicuculline. Neither of the epileptic phenomena can be used as a reliable index of cortical maturation.
Permanent Link: http://hdl.handle.net/11104/0283188