Number of the records: 1

Role of FoF1 ATP Synthase and its inhibitory peptide IF1 in both life stages of Trypanosoma brucei

SYSNO ASEP	0488335
Document Type	O - Others
R&D Document Type	Others
Title	Role of FoF1 ATP Synthase and its inhibitory peptide IF1 in both life stages of Trypanosoma brucei
Author(s)	Zíková, Alena (BC-A)_{RID, ORCID} Panicucci, Brian (BC-A) Gahura, Ondřej (BC-A)_{RID, ORCID}
Year of issue	2017
Language	eng - English
Country	CZ - Czech Republic
Keywords	IF1 ; ATP synthase ; T. brucei
Subject RIV	EB - Genetics ; Molecular Biology
OECD category	Biochemistry and molecular biology
R&D Projects	LL1205 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BC-A - RVO:60077344
Annotation	During hypoxia aerobic eukaryotes protect themselves against deleterious ATP depletion caused by the reversal of mitochondrial (mt) ATP synthase activity to ATP hydrolysis, which is inevitable consequence of the mt membrane potential (m) collapse in the lack of oxygen. The protection involves IF1, a protein inhibiting ATP hydrolysis by reversible binding to F1-ATPase, the catalytic sector of the enzyme.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2018

Number of the records: 1