A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

0485161 - BC 2018 RIV US eng J - Journal Article
Zíková, Alena - Verner, Zdeněk - Nenarokova, Anna - Michels, P.A.M. - Lukeš, Julius
A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex.
PLoS Pathogens. Roč. 13, č. 12 (2017), č. článku e1006679. ISSN 1553-7366. E-ISSN 1553-7374
R&D Projects: GA MŠMT LL1205; GA MŠMT LL1601; GA ČR GA17-22248S; GA ČR GA15-21974S; GA MŠMT(CZ) LQ1604
Institutional support: RVO:60077344
Keywords : life-cycle stages * african trypanosomes * adp/atp carrier * krebs cycle * forms * mitochondrion * reveals * protein * metabolism * glucose
OECD category: Biochemistry and molecular biology
Impact factor: 6.158, year: 2017

Trypanosoma brucei is a parasitic protist that causes significant health burden in sub-Saharan countries endemic for the tsetse fly (Glossina spp.). During the bloodmeal of this insect vector, the flagellate is transmitted to a variety of mammals, including humans, in which T. brucei subs. gambiense and T. brucei subs. rhodesiense cause human African trypanosomiasis. During its life cycle, T. brucei encounters and adapts to very diverse environments that differ in available nutrients. In the mammalian host, it exists in two major forms: the replicating long-slender bloodstream form (LS-BSF) and the nondividing short-stumpy bloodstream form (SS-BSF), the latter being pre-adapted to infect the insect vector.
Permanent Link: http://hdl.handle.net/11104/0280239