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Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic
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SYSNO ASEP 0475711 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic Author(s) Maršík, Petr (UEB-Q) RID, ORCID
Rezek, Jan (UEB-Q) RID, ORCID
Židková, Monika (UEB-Q)
Kramulová, Barbora (UEB-Q)
Tauchen, J. (CZ)
Vaněk, Tomáš (UEB-Q) RID, ORCIDNumber of authors 6 Source Title Chemosphere. - : Elsevier - ISSN 0045-6535
Roč. 171, MAR (2017), s. 97-105Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords chromatography-mass-spectrometry ; gas-chromatography ; human pharmaceuticals ; waste-water ; surface-water ; risk-assessment ; diclofenac ; ibuprofen ; products ; plants ; NSAID Surface water ; Pharmaceuticals ; GCxGC-TOFMS Elbe basin ; Czech Republic Subject RIV CE - Biochemistry OECD category Environmental biotechnology R&D Projects GA14-22593S GA ČR - Czech Science Foundation (CSF) Institutional support UEB-Q - RVO:61389030 UT WOS 000393931100012 DOI 10.1016/j.chemosphere.2016.12.055 Annotation Non-steroidal anti-inflammatory drugs (NSAIDs) belong to most used pharmaceuticals in the human and veterinary medicine. The widespread consumption of NSAIDs has led to their ubiquitous occurrence in water environment including large river systems. In the present study, concentrations of the five most frequently used NSAIDs (ibuprofen, diclofenac, naproxen, ketoprofen and indomethacin) were determined in the watercourses of the river Elbe basin in Czech Republic. The presence of the pharmaceuticals was measured at 29 sampling sites including urban and rural areas, small creeks and main tributaries of the Elbe monthly from April to December of 2011. For the NSAIDs quantitation, the comprehensive analytical method combing pentafluorobenzyl bromide (PFBBr) derivatization with highly sensitive twodimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS) was developed. Although the content of all NSAIDs varied at the particular sampling points significantly, total amount of particular compounds was relatively stable during all monitored periods with only non-significant increase in the spring and autumnal months. Ibuprofen was found to be the most abundant drug with maximum concentration of 3210 ng/L, followed by naproxen, diclofenac and ketoprofen (1423.8 ng/L, 1080 ng/L and 929.8 ng/L, respectively). Indomethacin was found only at several sampling sites (maximum concentration of 693 ng/L). Concentrations of all compounds except ibuprofen were significantly higher at sampling sites with low flow rates (creeks), followed by the biggest watercourses. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
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