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Deformability of Microtubules: An Atomistic Computational Study
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SYSNO ASEP 0473505 Document Type A - Abstract R&D Document Type O - Ostatní Title Deformability of Microtubules: An Atomistic Computational Study Author(s) Kučera, Ondřej (URE-Y) RID
Havelka, Daniel (URE-Y) RID
Deriu, M.A. (CH)
Cifra, Michal (URE-Y) RID, ORCID, SAISource Title Biophysical Journal. - : Cell Press - ISSN 0006-3495
Roč. 110, č. 3 (2016), s. 131-131Number of pages 1 s. Publication form Print - P Action 60th Annual Meeting of the Biophysical-Society Event date 27.02.2016 - 02.03.2016 VEvent location Los Angeles Country US - United States Event type WRD Language eng - English Country US - United States Keywords Microtubules ; Electrical polarity Subject RIV JA - Electronics ; Optoelectronics, Electrical Engineering R&D Projects GA15-17102S GA ČR - Czech Science Foundation (CSF) Institutional support URE-Y - RVO:67985882 UT WOS 000375093800151 DOI 10.1016/j.bpj.2015.11.751 Annotation Thanks to their material properties, microtubules can play complex variety of biological functions. Experimental studies have shown that mechanical characteristics of microtubules are length-dependent and anisotropic, however, the origin of this feature has not been traced down to the level of tubulin sequence yet. Here we use high-resolution elastic network model to show local deformations patterns in microtubule structure up to the level of individual amino acid residues. The mechanical strain within the molecular structure of a microtubule is, according to our results, localized to interdimer contacts with energetic preference of deformation in longitudinal contacts. These findings are in agreement with reported mechanical anisotropy of microtubules, i.e. higher Young's modulus in axial direction compared to radial direction. Our results contribute to understanding the origin of deformability of microtubules on the molecular level, which is important for prospective targeting of microtubules in medical therapeutic strategies Workplace Institute of Radio Engineering and Electronics Contact Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Year of Publishing 2017
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